disease | Atypical Endometrial Hyperplasia |
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bubble_chart Overview Endometrial hyperplasia is classified into simple hyperplasia, complex hyperplasia, and atypical hyperplasia. Atypical endometrial hyperplasia is a precancerous condition.
bubble_chart Diagnosis
- The age of onset is younger than that of carcinoma of endometrium, with an average age of about 34 years.
- Menstruation abnormalities or irregular bleeding.
- Due to endocrine disorders, it may be accompanied by infertility.
- Pathological examination is required for definitive diagnosis. Generally, diagnostic curettage (fractional curettage) is performed to obtain samples. If conditions permit, hysteroscopy can be performed to obtain suspicious tissue or microscopic curettage for pathological diagnosis.
bubble_chart Treatment Measures
During treatment
- , pay attention to the presence of polycystic ovaries, ovarian tumors with endocrine function, pituitary tumors, etc., in order to eliminate the disease cause for treatment. 2. Total hysterectomy. Mostly used for patients around menopause and younger patients with grade III atypical hyperplasia. 3. Drug therapy. Mostly used for younger patients (< 40歲),希望生育的患者。一般應用孕激素類藥物。 (1)安宮黃體酮,8 mg,口服,於月經第5天開始,每日1次,每月服22天。 (2)黃體酮110~30mg,肌注,於月經中期開始,每日1次,每月用7天。 以上適用於輕度不典型增生。 (3)甲地孕酮,160mg,口服,每日1次,持續用藥3個月。 (4)十八甲炔諾酮,3~4mg,口服,持續用藥3個月。 (5)己酸孕酮,500mg,肌注,每週1次,持續3個月。 (6)三苯氧胺,10~20mg,口服,每日1次,持續3個月,與孕激素類藥聯合應用 以上適用於中、重度不典型增生。藥物治療需嚴密隨訪,一般每3個月((1療程)後,診刮病理複查,根據病理結果再決定下一步治療方案。