Licorice (roasted), Immature Bitter Orange (broken, soaked in water, roasted dry), Bupleurum, Peony, equal parts of each.

bubble_chart Preparation and Dosage

Grind the above 4 ingredients into a fine powder. Take 3 grams with plain water, three times a day.

bubble_chart Efficacy

Soothing liver and regulating spleen, relieving depression and clearing heat.

bubble_chart Indications

Shaoyin disease, with yang constrained internally, leads to heat reversal; and the liver failing to act freely, qi depression causing reversal, cold hands and feet, or cough, or palpitations, or difficulty in urination, or abdominal pain, or diarrhea with tenesmus, with a wiry and thin pulse.

bubble_chart Formula Principles

This formula is the ancestral prescription for soothing the liver and relieving depression, regulating and harmonizing the liver and spleen. In the formula, Bupleurum can both alleviate liver depression and elevate clear yang to allow the outward penetration of stagnant heat, serving as the sovereign medicinal; Peony Root nourishes blood and astringes yin, paired with Bupleurum, one elevates and one astringes, allowing the stagnant heat to be resolved without damaging yin, acting as the minister medicinal; assisted by Immature Orange Fruit to regulate qi and resolve stuffiness, enhancing the effect of smoothing qi movement; Prepared Licorice Root alleviates urgency and harmonizes the middle, also harmonizing all the medicinals as the envoy.

bubble_chart Formula Modification

For cough, add Schisandra Fruit and Dried Ginger, which also treats diarrhea; for palpitations, add Cinnamon Twig; for difficulty in urination, add Poria; for abdominal pain, add Aconite Lateral Root; for diarrhea with tenesmus, add Longstamen Onion Bulb.

Effects on smooth muscle and the cardiovascular system. "Journal of Luzhou Medical College" 1980(2):9, The Cold-Limbs Powder compound formula significantly promotes macrophage function (P<0.005), exhibits notable inhibitory and antispasmodic effects on rabbit intestines, increases blood pressure, enhances myocardial contractility, and accelerates heart rate. It is believed that the effects of Sini Powder on the aforementioned smooth muscle and cardiovascular system are related to the Fructus Aurantii Immaturus it contains.