Rehmannia Root (Dried) 128 gm, Chinese Yam 64 gm, Cornus Fruit 64 gm, Poria 48 gm, Alisma Rhizome 48 gm, Moutan Bark 48 gm, Cinnamon Twig and Prepared Aconite Root 16 gm each.

bubble_chart Preparation and Dosage

Grind the above 8 ingredients into powder, mix with refined honey to form pills as large as a phoenix tree seed. Take 15 pills each time with wine, gradually increasing to 25 pills, administered twice a day.

bubble_chart Efficacy

Warming and tonifying kidney yang.

bubble_chart Indications

Insufficient kidney qi, soreness in the waist and weakness in the legs, limbs fearful of cold, lower abdominal tension, difficulty or frequency in urination, pale and swollen tongue texture, deep and thin pulse at the chi position; as well as phlegm-fluid retention causing wheezing and cough, edema, beriberi, consumptive thirst, and chronic diarrhea.

bubble_chart Formula Principles

In the formula, Rehmannia and Asiatic Cornelian Cherry Fruit nourish kidney yin and consolidate essential qi; Chinese Yam and Poria strengthen the spleen and drain dampness; Alisma expels water pathogens from the kidney; Peony Bark clears ministerial fire from the liver and gallbladder; Cinnamon Twig and Aconite Lateral Root warm and tonify the true fire of the life gate. When these herbs are combined, they collectively achieve the effect of warming and tonifying kidney yang.

bubble_chart Cautions and Contraindications

It is not suitable for those with symptoms of kidney yin deficiency and kidney fire inflammation, such as dry throat, dry mouth, red tongue, and scant coating.

bubble_chart Modern Application

Currently used for diabetes, hypothyroidism, chronic nephritis, adrenal cortical insufficiency, and bronchial asthma, among others, in cases of kidney qi deficiency.

1. Research on the metabolism of sexually transmitted diseases in "Japanese Kampo Medicine" 1982(4):10, administered Eight-Ingredient Rehmannia Pill to aged rats to explore glutathione metabolism, the results
   1. showed a significant increase in GSH and GSSG in the lens, suggesting that the Eight-Ingredient Rehmannia Pill has the effect of preventing senile internal visual obstruction;
   2. an increase in blood GSH, suggesting that the Eight-Ingredient Rehmannia Pill is involved in the glutathione metabolism of red blood cell membranes;
   3. an increase in GSH in the testes, indicating that the Eight-Ingredient Rehmannia Pill is involved in DNA synthesis and glutathione metabolism.
2. Research on anti-diabetic components in "Chinese Patent Drug Research" 1982(1):46, using Eight-Ingredient Rehmannia Pill powder orally administered to a rat model of diabetes induced by streptozotocin, the results showed that the Eight-Ingredient Rehmannia Pill effectively inhibited water intake, urine volume, blood sugar, and urine sugar levels. Among the single herbs that make up the formula, only Asiatic Cornelian Cherry Fruit was effective, and further identified ursolic acid and oleanolic acid as the effective anti-diabetic components.